Preheat air fryer to 350°F. Line a baking sheet with a wire cooling rack and set next to the air fryer.
In a mixing bowl, add breading ingredients (flour, smoked paprika, baking powder, garlic powder, onion powder, salt, and beer), and stir until well combined.
Add cauliflower florets to the mixing bowl and stir to coat. Add breaded florets to prepared wire rack and allow excess batter to drip off.
Spray basket of air fryer with nonstick cooking spray, add cauliflower in a single layer (depending on the amount of cauliflower and size of your air fryer, you may need to do this in batches). Spray lightly with nonstick cooking spray and air fry for 10 minutes.
Flip cauliflower florets over and spray lightly again with nonstick cooking spray. Air fry another 5 minutes.
While cauliflower is finishing in the air fryer, add all sauce ingredients (honey, bbq sauce, water, vinegar, chipotle chili powder, cayenne), and either microwave for about 3 minutes, or heat in a small saucepan until sauce is a looser consistency so you can easily toss the cauliflower in it.
Remove cauliflower from the air fryer and toss in the sauce. Serve with your favorite dipping sauce, or plain.