Glazed Chipotle Meatloaf Recipe

Not your average meatloaf recipe, this glazed chipotle meatloaf is packed with bold flavors like chipotle peppers, pepper jack cheese, chili powder and cumin!

Meatloaf gets a bad rep for being dry and boring, but this glazed chipotle meatloaf recipe is certainly an exception!  Bold spicy, smoky and savory flavor are combined in the meatloaf and it’s glazed with a mouthwatering smoky/sweet sauce that is irresistible!

Glazed Chipotle Meatloaf Recipe | Not your average meatloaf recipe, this glazed chipotle meatloaf is packed with bold flavors like chipotle peppers, pepper jack cheese, chili powder and cumin!  Slow cooker instructions too! | The Chunky Chef | #meatloaf #beefrecipes #groundbeefrecipes #chipotle #spicy #comfortfood #meatloafrecipe

I have to be honest with you… growing up, I wasn’t really a meatloaf fan.  It just didn’t appeal to me.  When I first moved out, we had meatloaf occasionally, but it was definitely not in the usual dinner rotation.  But now… we have it a LOT!  We also really love this Crockpot Meatloaf!

Chipotle meatloaf recipe

But lately, I’ve been experimenting with other flavors… and I came across this chipotle meatloaf recipe in a Southern Living magazine.  I tried it and was blown away!  The recipe was pretty spectacular, but I did add a few of my own changes (as I do with just about any recipe I try lol).


Unfortunately, a lot of meatloaf recipes come out dry and bland.  My favorite way to keep meatloaf moist is to not use dry breadcrumbs.  Instead, I use fresh bread and dice it up into super small pieces.  Then I soak those pieces in milk.  It has a really great way of still helping bind the meat together, but also keeping it really moist and delicious!

Another trick is to put a big pan of water on the rack underneath the meatloaf pan.  The steam created will make for the softest, moistest meatloaf ever!

Slices of chipotle meatloaf


That depends a lot on what temperature your oven is set to… but I generally bake meatloaf at either 350 or 375 F degrees.  At 350 F degrees, it will take about 60-90 minutes.  At 375 F degrees, it will take about 50-70 minutes.

All ovens will vary though, so I recommend checking the meatloaf on the early end of the time range.  I pull my meatloaf from the oven when it’s between 155-160 F degrees, and it will continue cooking as it sits.  You always want to let your meatloaf rest for 10 minutes after baking, so it stays juicy, and it helps it hold together better when you slice it.


  • Use your hands to mix.  Some people like to use a wooden spoon, but I find your hands are the best tools for the job.  Wear latex/nitrile gloves if you don’t want meatloaf hands… and mix just until everything is combined.
  • Save some of the ketchup sauce.  Make more sauce than you need, and after you slather some on the top, reserve the rest and drizzle it over the slices.
  • A meatloaf pan is awesome, but not absolutely necessary.  This is a great tutorial on how to make meatloaf without a special pan (without having it swimming in grease).
  • This meatloaf recipe can be made in the slow cooker!  In the recipe below, I have special instructions for this cooking method.

Plateful of chipotle meatloaf


  • Meatloaf pan – In case you’re in the market for one, this is the one I use, and LOVE!  Cleanup is a breeze.
  • Meat thermometer – Great for determining when your meatloaf is done, and the probe stays in it, and will beep when it hits 150-155 degrees, so you don’t have to keep continually checking it!
  • Nitrile gloves – save yourself some major hand scrubbing!
  • Chipotles in adobo sauce – this is the brand I like to use.

Forkful of chipotle meatloaf recipe




Glazed Chipotle Meatloaf Recipe | Not your average meatloaf recipe, this glazed chipotle meatloaf is packed with bold flavors like chipotle peppers, pepper jack cheese, chili powder and cumin!  Slow cooker instructions too! | The Chunky Chef | #meatloaf #beefrecipes #groundbeefrecipes #chipotle #spicy #comfortfood #meatloafrecipe

Glazed Chipotle Meatloaf Recipe

Not your average meatloaf recipe, this glazed chipotle meatloaf is packed with bold flavors like chipotle peppers, pepper jack cheese, chili powder and cumin!
4.5 from 18 votes
Prep Time 15 mins
Cook Time 1 hr
Total Time 1 hr 15 mins
Servings 4 - 6 servings
Calories 513


  • 1 medium yellow onion, diced
  • 1 Tbsp butter
  • 2-3 cloves garlic, minced
  • 3/4 cup finely diced bread slices
  • 1/4 cup milk
  • 2 lbs ground beef (I use ground chuck 80/20 or 85/15)
  • 2/3 cup shredded pepper jack cheese
  • 2 Tbsp fresh cilantro, minced
  • 2-3 chipotle peppers in adobo sauce, minced
  • 2 tsp chili powder
  • 1 tsp ground cumin
  • 1 tsp kosher salt
  • 1/2 tsp black pepper
  • 1 large egg, lightly beaten


  • 1/2 cup ketchup
  • 2-3 Tbsp adobo sauce from the can of chipotle peppers
  • 2 -3 Tbsp light brown sugar, packed


  • Preheat oven to 350 F degrees.  Add butter to small skillet and melt over MED heat.  Add onion and cook 4-5 minutes, until soft and slightly browned on the edges, stirring occasionally.  Add garlic and cook 1 minute.  Set aside to cool slightly.
  • Add diced bread pieces and milk to a large mixing bowl and stir to combine. Add beef, cheese, cilantro, minced chipotle peppers, chili powder, cumin, salt, pepper, beaten egg and cooked onion mixture.  Mix together until just combined.
  • Lightly spray a meatloaf pan with nonstick cooking spray.  Pat meatloaf into prepared pan.
  • Combine sauce ingredients in small bowl.  Slather about half the sauce on the top of meatloaf, and bake for 60-90 minutes, until meatloaf is about 150-155 F degrees.  Let stand 10 minutes before serving.  Use the remaining half of the sauce to spoon over the top or dip the meatloaf in as you eat 🙂


  • Complete steps 1-2 as written above.  Line a 4 quart or larger slow cooker with aluminum foil or parchment paper with holes poked into it every 1-2 inches (to drain the grease after cooking).  Shape meatloaf into a loaf shape and place on foil/parchment paper.  
  • Top with half the sauce, cover and cook on LOW for 4-5 hours, until meatloaf is 150-155 F degrees.  Carefully lift meatloaf out of slow cooker, letting grease drain through the holes.  If desired, place on baking sheet and broil a few minutes, until sauce is sticky.  Let stand 10 minutes before serving.


Recipe adapted from Southern Living Magazine 
Tried this recipe?Mention @the_chunky_chef or tag #thechunkychef!

If changing the recipe serving quantity, the recipe plugin will change the ingredient values for you, but it does NOT change the written instructions, those are manually added and not subject to a slider/button. You will have to extrapolate that multiplication to any amounts listed in the instructions.

For example: if an ingredient calls for 4 cups, and you doubled the recipe, it will automatically change to 8 cups. In the instructions, if I say “use 4 cups of cheese”, you will have to realize that since you doubled it, you use 8 cups, not 4



Glazed Chipotle Meatloaf Recipe | Not your average meatloaf recipe, this glazed chipotle meatloaf is packed with bold flavors like chipotle peppers, pepper jack cheese, chili powder and cumin!  Slow cooker instructions too! | The Chunky Chef | #meatloaf #beefrecipes #groundbeefrecipes #chipotle #spicy #comfortfood #meatloafrecipe

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Recipe Rating

23 comments on “Glazed Chipotle Meatloaf Recipe”

  1. This is the best Meatloaf I have ever had/made!  It was easy, flavorful and on the short list to make again!  Thank you!  

  2. This was Spectacular!!! Didn’t have bread so I used a very small amount of bread crumbs and added a little milk. It was incredible. I am a beginner cook but you made me a STAR tonight. Thank you!!!!

  3. This is our go to meatloaf recipe. This is awesome and I don’t even like meatloaf that much. I don’t use a pan. Instead I make a “round” and place on top of a cake rack (covered with foil w holes so that the grease will drain) that I set inside a baking sheet (also lined with foil for easier clean up). I really think it is the topping that makes this extra good and by not using a loaf pan, the sides of the meat loaf get nicely browned. Pair it with mashed sweet potatoes and a green veggie or salad and you have a fantastic dinner!!

  4. My husband challenged me to make a meatloaf better than his mothers, my husband is picky too so the challenge wasnt going to be easily won. But then I stumbled upon this holy grail of meatloaf recipes. It’s made it’s way to the favorites of the household, an easy put together, I crave it. We actually have leftovers in the fridge now from days ago and ive been so sad that I’ve been unable to eat them because we have had a stomach bug.

    Also I just googled the ultimate grilled cheese for a family competition. Guess where I landed?! I’m so pumped. I will be cheese queen!

  5. Simply amazing!

  6. My family loved this recipe and have requested it again and want to invite people over for it. What an endorsement from my family. My son says this is his 2nd favorite meatloaf. His grandma makes a bbq meatloaf that he has grown up with. One of my husbands friends is requesting to have this, so. The only change I made was to use 1# beef and 1# pork. So delicious and moist. Thank you for sharing. I am making this again tomorrow night.

  7. I am not a big fan of meatloaf, but this recipe is definitely a keeper.  I used breadcrumbs instead bread slices and omitted the cheese, and it was still delicious.

  8. Absolutely loved it! Paired it with carmelized onion mashed potatoes and pablano and corn relish. 

  9. Hi I want to make this fantastic meatloaf recipe but wondered what sides would go good with it. 

  10. Finally found a meatloaf recipe my family loves – it’s a hit! Plus, super easy to make. Because of meat on sale, I used 1# ground beef (90%) and 1# ground pork. I baked the meatloaf on a broiler pan so the fat dripped away from the meatloaf. (Used cooking spray the broiler rack. After patting meatloaf into prepared loaf pan, inverted the loaf pan onto the broiler rack/pan.)

  11. I’m just curious but you say to make the sauce then use half the sauce on top of meatloaf but then you never tell us what to do with the other half of sauce ?
    I just went and top the cooked meatloaf with the remaining sauce but was curious as to what was intended Thanks !

    • Hi Tommy 🙂 I mention it up in the body of the post, but I’ve added the instructions to the recipe as well for clarification. You can use the remaining half of the sauce to drizzle over the top of the cooked meatloaf or to dip it in as you eat it 🙂

  12. Fabulous Receipes, love it

  13. Love the idea of chipolte and meatloaf together. My wife is not a fan of meatloaf, but loves meatballs and chiles, maybe I can get her to try this!

  14. Meatloaf is one of my all-time favorite dishes that I rarely make! I LOVE the chipotle in this. This sounds so, super flavorful. Can’t wait to give it a go!

  15. Now this is a meatloaf full of flavor that I can get behind!

  16. Not gonna lie, I’m a huge sucker for a good meatloaf. And this looks like a GREAT meatloaf. Definitely need to try this recipe!

  17. You definitely kicked meatloaf up a notch! The glaze sounds awesome!

  18. Oh that glaze on top sounds amazing! I want a slice of this now!

  19. Wow this look like the perfect comfort dinner!

  20. This is one fabulous meatloaf! I have got to make this real soon!!!

  21. Pingback: Glazed Chipotle Meatloaf Recipe — The Chunky Chef | My Meals are on Wheels